This article was last reviewed on
This article waslast modified on July 11, 2018.
What are autoimmune diseases?

When the immune system functions normally, it produces a response intended to protect against harmful or foreign substances like bacteria, parasites, and cancerous cells. The response may include specific immune cells and/or antibodies. Autoimmune diseases arise when the immune system attacks one or more of the body's normal constituents as if they were invaders. When the immune system fails to recognize "self" it may produce immune cells or antibodies (called autoantibodies) that target its own cells, tissues, and/or organs. Those attacks cause inflammation and tissue damage that lead to autoimmune disorders.

There are 80-100 diseases that occur as a result of autoimmune responses and researchers suspect at least 40 additional diseases have an autoimmune basis. The National Institutes of Health (NIH) estimates that 23.5 million Americans are affected. Most autoimmune disorders are rare. However, the overall number of cases of autoimmune diseases is rising for unknown reasons. Women are disproportionately affected, representing 80% of people with autoimmune diseases. Some diseases such as lupus and Hashimoto thyroiditis affect 9-10 women for every man affected.

The cause of most autoimmune diseases is unknown, but it appears that there is an inherited predisposition in many cases. In a few types of autoimmune disease (such as rheumatic fever), a virus or infection with bacteria triggers an immune response and the antibodies or immune cells called T-cells attack normal cells because some part of their structure resembles a part of the infecting microorganism.

Autoimmune disorders fall into two general types: those that damage many organs (systemic autoimmune diseases) and those where only a single organ or tissue is directly damaged by the autoimmune process (localized). However, the distinctions become blurred as the effect of localized autoimmune disorders frequently extends beyond the targeted tissues, indirectly affecting other body organs and systems.

In some cases, the antibodies may not be directed at a specific tissue or organ. For example, antiphospholipid antibodies can react with substances (phospholipids) that are the normal constituents of platelets and the outermost layer of cells (cell membranes). This reaction can lead to the inappropriate formation of blood clots within blood vessels (thrombosis).

Autoimmune disorders can be difficult to recognize and diagnose. Autoimmune disorders affecting multiple organs can lead to highly variable signs and symptoms that can change in severity over time. Vague and slow to develop signs and symptoms may be present and can be misleading during diagnosis. Some of the more common symptoms of autoimmune disorders include fatigue, general feeling of being unwell (malaise), dizziness, joint pain, rash, and low grade fever.

Laboratory tests performed to diagnose autoimmune disorders depend on the particular disorder the health practitioner suspects a person has but usually include blood tests for one or more autoantibodies as well as tests for inflammation such as CRP and ESR.

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Examples of Disorders

The following is a list of examples of autoimmune disorders. Select a topic for more detailed information, including laboratory tests related to the condition.

For a more complete list, visit the Patient Information page of the American Autoimmune Related Diseases Association, Inc.


Below we provide links to resources with information on the following autoimmune disorders.


In some cases, a person may have more than one autoimmune disease. For example, individuals with Addison disease often have type 1 diabetes, while those with sclerosing cholangitis often have ulcerative colitis.

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Related Content

On This Site

Tests
Autoantibodies
C-Reactive Protein (CRP)
Erythrocyte Sedimentation Rate (ESR)

Elsewhere On The Web

American Autoimmune Related Diseases Association, Inc.
Womenshealth.gov: Autoimmune Diseases
MedlinePlus Medical Encyclopedia: Immune response
View Sources

Sources Used in Current Review

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(© 2015). Women's Health Research Center. Mayo Clinic. Available online at http://www.mayo.edu/research/centers-programs/womens-health-research-center/focus-areas/autoimmune-diseases through http://www.mayo.edu. Accessed on 5/25/2015.

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